Project Application Details

Name: Mithushan
Surname: Soundaranathan
DS username: njb18198
Email: mithushan.soundaranathan@strath.ac.uk
Institution: Strathclyde Institute of Pharmacy & Biomedical Sciences
Tel. no: 07376 726031
Position: PhD student

• A discrete element model coupled to the single particle model and liquid flow model to describe the liquid uptake, swelling and disintegration of a tablet.
• One multi-disciplinary journal paper: 1) High fidelity simulations of the pharmaceutical tablet disintegration process of various formulations
• Conference presentations/posters 1) SRPe Annual Conference (2022)
• Outputs will also have an impact in the pharmaceutical industry. The primary outcomes of this activity will be:
1) Reduced drug product development times and cost by utilising a digital design approach.
2) Reduced material waste (sustainable manufacturing) by replacing physical experiments with digital experiments using the models from this activity. This also includes the reduction of solvents needed for dissolution testing.
3) Optimised dissolution behaviour of tablets by having a scientific sound understanding of the link between the swelling of a single particle and the swelling of a tablet.
4) This will enable the modelling of the tablet swelling and disintegration without the need of experimental data.