Project Application Details

Angelika Kiepas – xmb20196

The user is a Strathclyde-funded REA PhD student in SIPBS, studying bioinformatics/computational biology. There is no associated budget, so subscription will be paid from the PI’s general fund.

We have already produced the largest, most comprehensive 16S phylogenetic tree of the Streptomyces genus (important for antibiotic discovery and industrial production), to aid classification and comparative genomic analysis. Being able to use ARCHIE-West will enable:

– efficient refinement of this tree to take into account variable evolutionary influences across the length of the sequence
– extension of the approach to multigene trees (more precise)
– pangenomic analysis within coherent organism groups identified using these trees
– metabolic modelling and comparisons between and within these groups

The phylogenetic analysis and (re)classification of Streptomyces is expected to lead to publications in journals such as Microbial Genomics and Molecular Biology and Evolution; pangenomic analyses are expected to be published in mBio or Microbial Genomics; metabolic modelling outputs are targeted at Molecular Systems Biology.